| EPSRC Reference: |
GR/R28775/01 |
| Title: |
Optimisation of Surface Enhanced Raman Spectroscopy For Label Free DNA Analysis |
| Principal Investigator: |
Cohen, Professor LF |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Physics |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 2001 |
Ends: |
31 October 2004 |
Value (£): |
258,343
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Healthcare |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Optimised surface enhanced Raman spectroscopy (SERS) is recognised to be an extremely powerful analytical tool for identifying DNA sequences, with the medical and forensic communities being the most obvious beneficiaries. In addition, SERS may well be applicable to micro-array based measurements and in contrast to fluorescence spectroscopy (which is the complementary technique), the time consuming and costly labelling of the DNA molecules should not be necessary for SERS. The optimisation procedure addressed in this proposal, principally involves the controlled (stable and reproducible) nanostructured fabrication of suitable metal or metal layered substrates to maximise the electromagnetic contribution to the SERS process forlabel free DNA analysis.This proposal is a response to the EPSRC second call for Metrology for Life Sciences. The project represents a strong interdisciplinary collaboration 'between physical and life scientists, and is strongly supported by medical, forensic and industrial collaborators. The co-investigators on this proposal provide the necessary expertise, to investigate the optimisation of SERS substrates for identification of DNA sequencies and to compare this behaviour with fluorescence spectroscopy.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |