| EPSRC Reference: |
GR/R19656/01 |
| Title: |
Reversible Covalent Chemistry: Poly-Catenanes and Dynamic Combinatorial Libraries |
| Principal Investigator: |
Sanders, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
05 March 2001 |
Ends: |
04 March 2004 |
Value (£): |
377,125
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| EPSRC Research Topic Classifications: |
| Combinatorial Chemistry |
Materials Synthesis & Growth |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Four iso-energetic exchange reactions which are complementary in their functional group tolerance and reaction conditions will be explored: hydrazone exchange (requiring mild acid), Pd-allyl transesterification (mild base), disulfide exchange (mild aqueous base) and alkene metathesis (neutral). Other reactions may be recruited where appropriate.Specific areas to be explored include (i) recursive synthesis of self-templated poly-catenanes based on donor-acceptor and C-H...O recognition; (ii) isolation from dynamic combinatorial libraries of cyclic and branched receptors based on natural products such as steroids, amino acids, sugars, alkaloids, and utilising a range of templates ranging from simple metal cations to natural products.Physical techniques employed will include photophysics, electrochemistry, affinity chromatography, gel phase MAS NMR spectroscopy and FTICR mass spectrometry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |