Details of Grant 

EPSRC Reference:	GR/R14323/02
Title:	Systematic Design of Complexes For Recognition & Binding To Dna as Probes & Therapeutic Agents
Principal Investigator:	Cronin, Professor L
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	School of Chemistry
Organisation:	University of Glasgow
Scheme:	Fast Stream
Starts:	01 August 2002	Ends:	31 August 2004	Value (£):	43,102
EPSRC Research Topic Classifications:	Biological & Medicinal Chem.
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
A structurally related range of ligands will be prepared that provide a cis-amino ligating group for the formation of complexes that may interact with DNA in a similar way to cisplatin and analogues. The novelty in our approach lies in the design and synthesis of ligands that can be systematically varied by the addition of pendent groups, which can alter the physical properties of the complex and enhance the interaction with DNA, whilst maintaining the same donor set and rigid ligand backbone around the metal ion. Our first set of ligands will be based upon the molecule cis,trans,tach and complexes of Pt and related salts will also be prepared. These will be then characterised and the interaction/binding of these complexes with mono-phosphate nucleotides and olgionucleotides will be examined. We intend to build upon these results by designing derivatives of these ligands that incorporate other functionality e.g. other DNA intercalation agents, peptides and other oligonucleotides. The feasibility of these modifications will be examined by molecular modelling studies before proceeding to further stages of synthesis and characterisation. In this way we hope to provide a flexible route to an understanding of the factors that allow molecules such as cisplatin to bind to DNA and, therefore, build on this in the design of agents that are both stronger DNA binders, and have specificity and incorporate other functional properties.
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Organisation Website:	http://www.gla.ac.uk