| EPSRC Reference: |
GR/R09787/01 |
| Title: |
Cancellous Bone: Modelling & Measuring Properties In Relation To Pathological Changes |
| Principal Investigator: |
Smith, Professor CW |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Engineering Computer Science and Maths |
| Organisation: |
University of Exeter |
| Scheme: |
Fast Stream |
| Starts: |
01 October 2000 |
Ends: |
30 June 2004 |
Value (£): |
62,166
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Aerospace, Defence and Marine |
Healthcare |
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| Related Grants: |
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Summary on Grant Application Form |
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Cancellous bone is a cellular solid and its elastic and some fracture properties can be mode1led using simple geometrical based analytical expressions. The pathologies of several bone diseases eg osteoporosis, lead to increased risk of fracture in the femoral neck where cancellous bone predominates. Prediction of fracture risk in individuals from bone mineral density data obtained by X-ray or other techniques is highly desirable but is only moderately successful in some cases, particularly at the onset of disease. The applicant proposes to develop geometrically based three dimensional models of cancellous bone, using directly measured material properties of isolated trabeculae in normal, aged and diseased cancellous bone, along with geometrical changes eg trabeculae thinning. The effect of fatigue damage will be incorporated into the models. The models will demonstrate the relationship between the pathological changes in material properties and geometry and the consequent increase in fracture risk. It is expected that general guidelines for clinicians concerning bone loss and increased fracture risk will result from the models.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |