| EPSRC Reference: |
GR/R06816/01 |
| Title: |
High Resolution Optical Tomographic Imaging of In Vivo Micro-Circulation |
| Principal Investigator: |
Wang, Professor R |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Medicine |
| Organisation: |
Keele University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
15 June 2001 |
Ends: |
28 February 2002 |
Value (£): |
238,151
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
Medical Imaging |
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Summary on Grant Application Form |
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Doppler Optical coherence tomography (DOCT) is a recent advent and powerful technique that can provide microscopic tomographic imaging of microcirculations simultaneous with microstructure features of biological tissue. This proposal aims to develop a real world DOCT system capable of characterising amnd monitoring blood flow functionally with high spatial resolution (2-10 microns) at user-specified locations in highly scattering biological tissues, to aid diagnosis and assessment of tissue abnormalities, surgical and phamacological interventions. We will first resolve the physics and engineering problems underlying DOCT in order to clarify what is the maximum imaging depth and how instrumentation parameters and optical properties of both the flowing and static medium might influence the system performances. The technique will then be applied to record the DOCT images through highly scattering media and animal models in vivo. We intend to establish the ultimate limits of this technology and to define precisely the required specifications of an optimal system that is suitable for clinical use. It is believed that the instrument which which permits high resolution functional imaging of microcirculation will impact significantly on monitoring perfusion and viability before, during and after reconstructive procedures, determining the efficicacy of pharmacological intervention for failing surgical skin flaps or replants,etc.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.keele.ac.uk |