| EPSRC Reference: |
GR/N66711/01 |
| Title: |
MODELLING STOCHASTIC ACTIVATION OF T CELLS |
| Principal Investigator: |
Burroughs, Professor N |
| Other Investigators: |
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| Department: |
Mathematics |
| Organisation: |
University of Warwick |
| Scheme: |
Fast Stream |
| Starts: |
01 September 2000 |
Ends: |
31 March 2003 |
Value (£): |
62,354
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| EPSRC Research Topic Classifications: |
| Statistics & Appl. Probability |
Theoretical biology |
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Summary on Grant Application Form |
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A mathematical model of T cell activation by signals from the random antigen environment ( self and foreign ) incorporating thresholding at the receptor and cellular levels is proposed for the examination of fundamental and clinical issues in immunology. The model will extend previous work ( submitted ), generalising to more realistic antigenPresentation patterns, examine alternative models of molecular kinetics ( for which there is experimental support ), and consider the effects of noise in the system on the ability of the model to reproduce experimentally observed specificities of T cells within the context of low affinity receptors. The mathematical framework is applicable to more general biological systems, and represents a new area of mathematical biology.This proposal represents basic research in mathematical applications to the life sciences. It will make a valuable contribution to the debate on T cell activation, and more generally introduced a mathematical methodology for the modelling and analysis of stochasticity in biological systems. It addresses a high priority area of the life sciences remit and will form the basis of subsequent applications to EPSRC.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.warwick.ac.uk |