| EPSRC Reference: |
GR/N63666/01 |
| Title: |
STEREOSELECTIVE SYNTHESIS OF HYDROXYCORNEXISTIN USING DOMINO METATHESIS REACTIONS |
| Principal Investigator: |
Clark, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
185,648
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The unusual structure of the cornexistins coupled with their potent and selective herbicidal activity makes them highly attractive targets for total synthesis. They present a variety of synthetic challenges, especially wuth regards to medium-ring construction and stereocontrol. The objective of the work outlined in this proposal is the development of an efficient and completely general strategy for the synthesis of hydroxycornexistin and cornexistin analogues.An efficient total synthesis of hydroxycornexistin will require the development of new strategies for the construction of medium -ring carbocycles. Two approaches to construction of core of the natural product will be explored. In the first approach, separate ring-closing metathesis reactions will be used to assemble the nine-membered ring and to control the stereochemistry of exocyclic alkene. The second more convergent strategy will employ a domino ring-closing, ring -opening, ring-closing sequence to address the issUues of medium-ring construction and control of the exocyclic alkene geometry in a single operation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |