Details of Grant 

EPSRC Reference:	GR/N36066/02
Title:	MECHANISM AND APPLICATION OF CHIRAL LEWIS-ACID CATALYSED AZA-DIELS-ALDER REACTIONS
Principal Investigator:	Whiting, Professor A
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Department:	Chemistry
Organisation:	Durham, University of
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2001	Ends:	30 September 2003	Value (£):	94,136
EPSRC Research Topic Classifications:	Asymmetric Chemistry Catalysis & Applied Catalysis
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Summary on Grant Application Form
The programme involves the use of a range of physical organic and analytical methods to determine the mechanism of action of four catalytic asymmetric systems which were recently discovered in our laboratories. These catalysts induce high asymmetric systems which were recently discovered in our laboratories. These catalysts induce high asymmetric induction in the aza-Diels-Alder reaction of an N-aryl electron deficient imine with Danishefsky's diene. The mechanistic study will also involve an in-depth study of the scope of the catalytic processes, examining its applicability on different diene and dienophile combinations. The final part of the project will involve a detailed study to develop new synthetic methods for the conversion of the aza-Diels-Alder adducts into useful asymmetric synthons, particularly for the preparation of new potential alpha- and beta-glucosidase inhibitors.
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