| EPSRC Reference: |
GR/N34901/01 |
| Title: |
A NEW STRATEGY FOR THE SYNTHESIS OF CHIRAL PHOSPHINES AND BIS-PHOSPHINES |
| Principal Investigator: |
Gouverneur, Professor V |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
63,112
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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Chiral phosphine ligands are of key importance in asymmetric synthesis of optically active products by homogeneous catalysis using organometallic species. Although many chiral phosphines and bis-phosphines have been reported, there remains a need for novel and easily accessible ligands with the potential for structural fine-tuning, which may improve results in processes that at present give only modest selectivities. The proposed research is aimed to develop a new route to chiral cyclic phosphines using the ring closing metathesis (RCM) of phosphino-borane dienes, trienes or tetraenes as the key step. The first part of the project will combine the RCM with the chemistry of Juge (synthesis of phosphines from chiral oxazaphospholidine complex) to prepare a wide range of new cyclic chiral phosphines. In the second part, new designed phosphines including chelating ether function will be prepared using asymmetric RCM processes. Several strategies will be studied including (1) the use of a chiral boron species as the chiral auxiliary, (2) the kinetic resolution of racemic triene or (3) the asymmetric desymmetrisation of tetraenes. The last two strategies will involve the use of chiral catalysts. The last part of the project will be focused on the evaluation of these new chiral phosphine ligands.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |