| EPSRC Reference: |
GR/N28733/01 |
| Title: |
REGIOSELECTIVE EFFECTS IN PALLADLIUM CATALYSED ALLYLIC SUBSTITUTION |
| Principal Investigator: |
Williams, Professor JM |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 2001 |
Ends: |
30 June 2002 |
Value (£): |
72,352
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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This proposal is a study of ligand control in palladium catalysed allylic substitution. The regiocontrol of the substitution reaction has been observed to be subject to a memory effect when using tricyclohexylphosphine as the co-ligand.Optimisation of regiocontrol will be performed, as well as studies towards retaining the enantioselectivity of enantiomerically enriched allyl acetates.Applications of this chemistry towards a few useful synthetic building blocks are identified.Additionally, a speculative catalytic cycle is proposed where a substrate is electronically activated using palladium catalysed allylic substitution to achieve turnover in the chiral auxiliary.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |