| EPSRC Reference: |
GR/N23882/01 |
| Title: |
LATENT ACTIVE GLYCOSYL COUPLING METHODOLOGY FOR THE SYNTHESIS OF OLIGOSACCHARIDES |
| Principal Investigator: |
Leslie, Dr R |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry and Physics |
| Organisation: |
Nottingham Trent University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
31 January 2004 |
Value (£): |
63,158
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed investigation seeks to develop novel methodology for glycosidic bong formation using a latent/active strategy. In particular this work will seek to address the limitations of current methods by improving both donor reactivity and ease of latent-active functional group interconversion. This will have the effect of improving yields while simplifying the process of carbohydrate syntheses. The work will be carried out in three parts (a) a systematic and extensive study of the synthesis of the latent ester moiety, conversion to the active thionoester and subsequent glycoside bond forming reaction, (b) the development of protective group strategies, complementary to the latent anomeric ester function, for preparation of monosaccharide building blocks leading to an iterative carbohydrate synthesis, (c) application of this methodology to the synthesis of a biologically important oligosaccharide.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ntu.ac.uk |