| EPSRC Reference: |
GR/N23035/01 |
| Title: |
NEW APPROACHES TO BIOLOGICALLY ACTIVE AMINES USING COBALT TEMPLATE SYNTHESES |
| Principal Investigator: |
Golding, Professor B |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
Newcastle University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
28 October 2000 |
Ends: |
27 October 2003 |
Value (£): |
170,914
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The project is concerned with the development of new synthetic methodology based on stable, non-dissociable cobalt (III) templates. This methodology will be applied to the synthesis of unusual polyamines, amino acids and heterocycles, some of which may exhibit significant activity against biological targets implicated in the molecular pathology of cancer and other diseases. There are many advantages to the proposed synthetic strategy with cobalt templates over the use of traditional organic protecting and activating groups, including the ability to obtain single enantiomers of chiral molecules by exploiting the chirality of the cobalt centre. The research will be largely focused on imine complexes as these present many opportunities to achieve C-C and C-N bond formations, which can be coupled, if required, within the same reaction sequence. The acidic/basic and electrophillic/nucleophillic character of different sites can be manipulated to orchestrate the chemistry, which can lead via a cyclisation to heterocyclic products.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ncl.ac.uk |