| EPSRC Reference: |
GR/N17225/01 |
| Title: |
(ROPA) MATHEMATICAL MODELLING OF THE DEVELOPMENT OF DUCTAL CARCINOMA IN SITU OF THE BREAST |
| Principal Investigator: |
Lewis, Professor C |
| Other Investigators: |
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| Department: |
Medicine and Biomedical Science |
| Organisation: |
University of Sheffield |
| Scheme: |
ROPA |
| Starts: |
03 January 2001 |
Ends: |
02 January 2003 |
Value (£): |
85,258
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| EPSRC Research Topic Classifications: |
| Biophysics |
Continuum Mechanics |
| Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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This project will develop and analyse realistic mathematical models of ductal carcinoma in situ (DCIS) which describe interactions between the expansive force created by tumour cell proliferation within the ducts and the stress that develops in the compliant ductal wall. The models, whose formulation will involve coupling of tumour growth models with those describing the mechanical response of the ductal wall, will establish whether correlations exist between the morphology, size and malignant potential of different forms of DCIS, and how its progression is affected by tumour cell-derived proteases that alter the mechanical properties of the ductal walls.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |