| EPSRC Reference: |
GR/N13180/01 |
| Title: |
DYNAMICS OF MICROBUBBLE ULTRASONIC CONTRAST AGENTS: EXPERIMENTAL AND THEORETICAL INVESTIGATIONS |
| Principal Investigator: |
McDicken, Professor WN |
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| Project Partners: |
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| Department: |
Medical and Radiological Sciences |
| Organisation: |
University of Edinburgh |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
376,503
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| EPSRC Research Topic Classifications: |
| Instrumentation Eng. & Dev. |
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Summary on Grant Application Form |
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Encapsulated, gas-filled microbubbles are now used increasingly in ultrasonic scanning for enhancing the ultrasound signal from difficult-to-image anatomical sites. However the response of these microbubbles to the acoustic pulse is not well documented, in particular with respect to parameters such as varying capsule thickness, distribution and size. Of great interest is also the life cycle phenomena that accompany bubble oscillations, such as rupture or cavitation. The statistical dynamics of cavities will be addressed by analyzing those problems in terms of a heirarchy of mathematical models from gas bubbles to elastic capsules, from isolated cavities to a population thereof, from deterministic to stochastic interactions with appropriate variations in the frequency, amplitude, phase and the pulse shape of the isonating field. The phenomenon of stochastic resonance from bubbles forced to periodically move in response to an acoustic pressure field could be usefully exploited in practical applications. The main aim of the experimental and theoretical investigation is to discover and account for behaviours that are totally absent in the analyses of isolated microbubbles and investigate their impact on diagnostic and therapeutic applications of ultrasound.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ed.ac.uk |