Details of Grant 

EPSRC Reference:	GR/N07479/01
Title:	COMBINATORIAL APPROACH TO THE DEVELOPMENT OF NEW ASSYMETRIC PHASE-TRANSFER CATALYSTS
Principal Investigator:	Lygo, Professor B
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Chemistry
Organisation:	University of Nottingham
Scheme:	Standard Research (Pre-FEC)
Starts:	01 November 2000	Ends:	31 October 2003	Value (£):	237,042
EPSRC Research Topic Classifications:	Combinatorial Chemistry
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
We propose to develop a combinatorial approach to the identification and optimisation of quaternary ammonium salt asymmetric phase-transfer catalysts. This work will initially involve the development of reaction processes involving the alkylation of amino acid imines, that are compatible with the generation of catalyst libraries. We will then use these processes to develop effective strategies for the identification/optimisation of the phase-transfer catalysts.Once this initial phase of the work is complete we will seek to extend the range of alkylation substrates that can be incorporated into this methodology and then ultimately we will investigate application of this strategy to other types of reaction process (e.g. epoxidation).
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Organisation Website:	http://www.nottingham.ac.uk