| EPSRC Reference: |
GR/M97466/01 |
| Title: |
A CLEAN APPROACH TO RADICAL CHEMISTRY BASED ON DISCOVERIES WITH PHOSPHORUS-CENTRED RADICALS |
| Principal Investigator: |
Murphy, Professor JA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2000 |
Ends: |
31 August 2003 |
Value (£): |
170,868
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This project aims to build on recent discoveries in our laboratories that showed that hypophosphorous acid and its salts can mediate radical cyclisation reactions in high yield and with none of the problems associated with the currently used toxic reagent tributyltin hydride. We aim to explore the scope of the reaction and the variation in reactivity across a range of radical precursors derived from low-valence phosphorus compounds. We further propose to apply the chemistry to the synthesis of compounds which are of medicinal importance, including the anti-Alzheimer drug galanthamine and the analgesic morphinans.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |