| EPSRC Reference: |
GR/M94205/01 |
| Title: |
SOLUBLE BLOCK CO-POLYACRYLAMIDES. STRUCTURE-PROPERTY CORRELATIONS IN POLYMER THERAPEUTICS |
| Principal Investigator: |
Brocchini, Professor SJ |
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| Department: |
School of Pharmacy |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2000 |
Ends: |
31 August 2001 |
Value (£): |
48,059
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Covalent conjugation of a drug to a soluble, biocompatible polymer can exhibit improved therapeutic efficacy compared to the free, unconjugated drug. Currently four polyacrylamide (HPMA) copolymer-drug conjugates are undergoing clinical evaluation. While there is significant biological rationale for the development of these therapeutic agents, there is much less known about the chemical rationale. One chemical aspect relates to controlling and defining the placement of the drug conjugating pendent chains along the polymer mainchain. The main subject of this application is to prepare well characterised block co-polymer precursors that can be used as common intermediates to prepare structurally defined water soluble families of blocked co-polyacrylamide-doxorubicin conjugates. Solution phase physiocechemical properties determined as a means to formulate structure-property correlations so relevant properties important to the development of polymer therapeutics can be maximised (eg degree of drug loading and conjugate solubility). Candidate conjugates will be evaluated using routine in vitro biological assays to correlate physiochemical and biological structure-property relationships.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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