| EPSRC Reference: |
GR/M86644/01 |
| Title: |
TOTAL SYNTHESIS OF PHOMACTINS |
| Principal Investigator: |
Thomas, Professor EJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
02 February 2000 |
Ends: |
01 July 2003 |
Value (£): |
165,032
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The phomactins are 'a family of diterpenes which exhibit PAF antagonistic activity. It is proposed to develop a .flexible synthetic approach to the phomactins which will provide improved access to several members.of,this`' family. Following on from preliminary studies already carried out, it is proposed,to complete a synthesis of a heavily functionalized methylenecyclohexaneand investigate the cyclisation of this to form the skeleton of the.phomactins. Final modifications will lead to phomactins D and E. Subsequent work should lead to the completion of syntheses of phomactin A and Sch.' 49028. This programme should provide improved access to phomactins for studies of their biological activity: -
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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