| EPSRC Reference: |
GR/M77567/01 |
| Title: |
ARYLGERMANE BASED IMMOBILISATION STRATEGIES FOR SOLID PHASE ORGANIC SYNTHESIS |
| Principal Investigator: |
Spivey, Professor A |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
59,475
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| EPSRC Research Topic Classifications: |
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| Chemicals |
Food and Drink |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We have developed a new method for the immobilisation of lithiated aromatic molecules to commercial argogel resin using a chlorogermane based 'linker' and shown that this allows for library preparation and subsequent cleavage with concomitant functionalisation by electrophilic ipso-degermylation. We propose here to develop a complementary di-metallogermane based 'linker' for which immobilisation is achieved by a palladium catalysed coupling reaction which circumvents the need to lithiate the aromatic molecule (thereby allowing a much wider range of aromatic molecules to be immobilised). Furthermore, we plan to extend the range of electrophiles able to effect degermylative cleavage to encompass particularly C-C bond formation via a Friedel-Crafts process and iodolabelling using NaI-oxidant combinations. Finally, we plan to extend the versatility and economy of our arylgermane based immobilisation to allow for 'scale-up' (i.e. preparation of multi-gram quantities of material) by preparing soluble, germanium functionalised, non-crosslinked polystyrene based supports for carrying out chemistry analogous to that carried out on the germanium linker/argogel combination used to develop this chemistry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |