| EPSRC Reference: |
GR/M73293/02 |
| Title: |
PLANAR CHIRAL CATIONIC ALLYL COMPLEXES IN ASYMMETRIC SYNTHESIS |
| Principal Investigator: |
Kocienski, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
30 October 2000 |
Ends: |
29 October 2002 |
Value (£): |
178,949
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Unlike p-allyl palladium complexes, p-allyl molybdenum complexes react with comparatively hard organometallic nucleophiles. Preliminary results indicate that organocopper (I) reagents, for example, add to cationic p-allyl molybdenum complexes with inversion of configuration. In certain circumstances the regiochemistry of attack previously through to be subject to ligand control (Faller), can be subverted leading to a practical method for asymmetric alkylation. By using planar chiral complexes and chiral organometallic nucleophiles, new C-C bonds can be generated in highly hindered circumstances with the simultaneous creation of two stereogenic centres. The method offers an opportunity for the appendage of unsaturated carbon chains to heterocyclic rings which should be applicable to a wide range of natural products.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |