| EPSRC Reference: |
GR/M63782/01 |
| Title: |
ASYMMETRIC CATALYSIS IN SUPERCRITICAL CARBON DIOXIDE |
| Principal Investigator: |
Xiao, Professor J |
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| Department: |
Chemistry |
| Organisation: |
University of Liverpool |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2000 |
Ends: |
31 March 2003 |
Value (£): |
63,057
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Although supercritical carbon dioxide has been put forward as one of the most attractive alternatives to hazardous and/or environmentally unacceptable organic solvents for industrial processes, the number of actual applications in catalysis, in particular, is still relatively few. This arises from the virtual insolubility of conventional metal catalysts in supercritical carbon dioxide. We, and others, have shown that by attaching long perfluoroalkyl units to ligands, catalytically active metal complexes can be dissolved in supercritical carbon dioxide and high levels of catalytic activity can be achieved. Here, we seek to extend this approach to supercritical carbon dioxide-soluble chiral metal complexes for asymmetric synthesis. The target ligands, perfluoroalkyl-derivatised analogues of BINAP and BINAPHOS, will be prepared by the development of established synthetic procedures. We intend to use these ligands for ruthenium and rhodium-catalysed hydrogenations and hydroformylations of a series of model, prochiral, substrates to establish the efficacy of the process. Furthermore, we intend to show that 100% recovery and recycle of these metal catalysts can be achieved via either supercritical or fluorous extraction procedures.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.liv.ac.uk |