| EPSRC Reference: |
GR/M46488/01 |
| Title: |
AN ULTRA-SENSITIVE FIELD-CYCLED PEDRI IMAGER FOR STUDYING FREE RADICALS IN VIVO |
| Principal Investigator: |
Lurie, Professor DJ |
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| Department: |
Biomedical Physics and Bioengineering |
| Organisation: |
University of Aberdeen |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 1999 |
Ends: |
30 June 2002 |
Value (£): |
335,047
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| EPSRC Research Topic Classifications: |
| Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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It is widely believed that endogenous free radicals are associated with the pathogenesis of many diseases, but the evidence for free radical involvement is largely indirect. There is a need for a technique which can detect and image free radicals in living animals. The applicants have developed magnetic resonance methods to image free radicals, particularly proton-electron double-resonance imaging (PEDRI). Field-cycled PEDRI (FC-PEDRI) can increase the sensitivity, by applying the EPR irradiation at low field and detecting the NMR signals at much higher field strength. An FC-PEDRI imager with detection at 59 mT has allowed us to begin to study naturally-generated free radicals such as nitric oxide in biological systems. We propose to build an FC-PEDRI imager with greatly increased sensitivity, based on a field-cycled superconducting magnet with a detection field of up to 1 Tesla, capable of detecting free radicals in vivo down to concentrations of 100-200nM. The increased sensitivity will allow us to apply the technique in a number of clinically-relevant animal models of human diseases which are being explored by our clinical collaborations, all of whom are acknowledged experts in their fields. These include the study of free radicals in experimental autoimmune uveoretinitis, nephrotoxic nephritis and sepsis.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.abdn.ac.uk |