| EPSRC Reference: |
GR/M46181/01 |
| Title: |
ROPA: PREPARATION OF NUCLEASE RESISTANT ANTISENSE OLIGONUCLEOTIDES WITH POTENTIAL ACTIVITY AGAINST TNF- |
| Principal Investigator: |
Roberts, Professor S |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Liverpool |
| Scheme: |
ROPA |
| Starts: |
19 April 1999 |
Ends: |
18 July 2002 |
Value (£): |
123,278
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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The oligodeoxynucleotide 5'-TACTTACATAAA acts as an antisense molecule inhibiting production of TNF-x. Clinical studies are currently proceeding to investigate the topical use of this material for the treatment of psoriasis.The Liverpool team (Cosstick. O'Neil and Roberts) have experience in the synthesis of nucleotide analogue which exhibit stability towards phosphorylases and nucleases. In this programme we wish to incorporate synthetic nucleotides into the aforementioned dodecanucleotide and test their effectiveness as TNF-x antisense agents. Dr Mark Gumbleton (Cardiff University) has agreed to perform the key biological tests (see later).
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.liv.ac.uk |