| EPSRC Reference: |
GR/M41971/01 |
| Title: |
THE ROLE OF MACROPHAGES IN SOLID TUMOUR GROWTH |
| Principal Investigator: |
Byrne, Professor H |
| Other Investigators: |
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| Department: |
Theoretical Mechanics |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
30 September 2001 |
Value (£): |
52,804
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| EPSRC Research Topic Classifications: |
| Non-linear Systems Mathematics |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We propose the development of a new generation of mathematical models to describe the role of macrophages in avascular tumour growth. The models will enable us to compare the impact that fixed and evolving prepatterns associated with the underlying tumour structure have on the formation by the infiltrating macrophages of secondary patterns, and also to study the way in which tumour-cell-macrophage interactions influence the tumour's development. The models will include fixed and moving free boundaries to denote interfaces such as the outer tumour boundary. The principle focus of the project is the novel mathematics that be needed to study these models.Ongoing collaboration with Claire Lewis' (CEL) group will ensure that our models simulate real experimental observation and hopefully provide valuable insight into the complex role played by macrophages in solid tumour growth. Specifically, we aim to explain the observed correlation between the proportion of a tumour that is hypoxic (low oxygen levels) and the number of macrophages that infiltrate it and also to assess the feasibility of using macrophages to deliver anticanoer drugs to the notoriously drug-resistant hypoxic regions. It is anticipated that investigations will yield interesting mathematical advances and help experimentalists improve cancer management.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |