| EPSRC Reference: |
GR/M41230/01 |
| Title: |
INTRAMOLECULAR RADICAL ADDITIONS TO PYRIDINES, QUINOLINES AND RELATED HETEROAROMATICS |
| Principal Investigator: |
Harrowven, Professor DC |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
48,097
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Our programme of research will investigate intramolecular additions of carbon centred radicals to pyridines, quinolines and related heteroaromatic compounds. In particular, we intend to delineate the scope of the reaction with respect to (I) additions to C-2, C-3 and C-4; (ii) five, six and higher ring closures and (iii) the effect of pH and substituents on the mode of cyclisation and efficiency of reaction.Parallel studies will seek to apply the chemistry developed to syntheses of some biologically interesting natural products. Targets include the yohimbine alkoloids (which have been shown to be effective in the treatment of penile erectile dysfunction), camptothecin (which displays cytotoxicity towards human ovarian, colon, lung, gastric and CNS cancers) and schumanniophytine (active against the HIV-IIIB virus and type 1 herpes somplex virus.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |