| EPSRC Reference: |
GR/M30654/01 |
| Title: |
NEW STRATEGIES FOR THE RAPID AND CONVERGENT SYNTHESIS OF MARINE POLYCYCLIC ETHER TOXINS |
| Principal Investigator: |
Clark, Professor J |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
11 January 1999 |
Ends: |
10 July 2002 |
Value (£): |
151,285
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The marine polycyclic ether toxins are important targets because of their structural complexity and putative biological activity. They represent a formidable synthetic challenge, especially with regard to the issues of ring construction and stereocontrol. An efficient total synthesis of any of these natural products will require the invention of new strategies and reactions for the construction of fused polycyclic systems. The proposed work will involve the synthesis of complex polycyclic systems in a novel, elegant and convergent manner using ring-closing metathesis as the pivotal reaction to effect ring construction. Ring-closing metathesis will be used to construct single-ring building blocks in enantiomerically pure form, and to prepare large polycyclic fragments by the union of these single-ring systems. This novel strategy will be based on our successful preliminary studies. The use of double ring-closing metathesis reactions for the two-directional synthesis of fragments of the polycyclic ether toxins will also be explored. This highly efficient strategy will be used to prepare tricyclic portions of some of the natural products in order to demonstrate the synthetic potential of this approach to polycyclic ether construction.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |