| EPSRC Reference: |
GR/M29511/01 |
| Title: |
ALKENE METATHESIS: A SIMPLIFIED STRATEGY FOR THE TOTAL SYNTHESIS OF -LACTAM ANTIBIOTICS |
| Principal Investigator: |
Barrett, Professor T |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
ROPA |
| Starts: |
28 June 1999 |
Ends: |
27 November 2000 |
Value (£): |
50,851
|
| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
|
|
| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The objectives of this proposal are the applications of ring closing alkene metathesis reactions in the total synthesis of complex b-lactam antibiotics. A series of polyfunctional dienes or enynes will be elaborated from simple precursors using sigmatropic rearrangements, cyclopropenylation or acyliminium ion chemistry. Subsequent reaction with metal carbenes such as Cl2(Cy3P)2Ru=CHPh should provide access to the corresponding bicyclic b-lactam antibiotics. The method should be applicable for diverse cephems, carbacephems, oxacephems, and the corresponding1-azabicyclo[5.2.0]nonan-9-one systems including novel compounds for bioassay against common bacterial pathogens including resistant organisms.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.imperial.ac.uk |