Details of Grant 

EPSRC Reference:	GR/M13558/01
Title:	SMALL RING N-OXIDES IN THE SYNTHESIS OF HIGHLY FUNCTIONALISED NITROGEN HETEROCYCLES
Principal Investigator:	ONeil, Dr IA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Liverpool
Scheme:	Standard Research (Pre-FEC)
Starts:	01 February 1999	Ends:	31 January 2002	Value (£):	151,107
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
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Panel History:
Summary on Grant Application Form
In preliminary studies we have shown that azetidine N-oxides can be prepared and converted to functionalised hydoxylamines under mild and high yielding conditions. Furthermore we have shown that these hydroxylmines undergo a reverse-cope cyclisation to give functionalised piperidines in good yield. We wish to develop our initial work into a general synthesis of chiral piperidines.Furthermore we wish to extend our results by examining the ring opening of azridines with organometallic reagents.We also wish to study the analogous reactions of aziridine N-oxides which have been shown to be more reactive.We wish to utilise our new methodology in the synthesis of several alkaloid natural products.
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Organisation Website:	http://www.liv.ac.uk