| EPSRC Reference: |
GR/M13022/01 |
| Title: |
TITANIUM(IV) SALEN COMPLEXES AS ASYMMETRIC CATALYSTS FOR THE SYNTHESIS OF CYANOHYDRINS AND RELATED SPECIES |
| Principal Investigator: |
North, Professor M |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Unknown (Data Transfer) |
| Organisation: |
Bangor University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
23 September 1998 |
Ends: |
30 September 1999 |
Value (£): |
16,152
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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It is proposed to develop titanium complexes with chiral salen derived ligands as chiral catalysts for the asymmetric addition of hydrogen cyanide and trimethylsilyl cyanide to aldehydes and ketones. Preliminary investigations have shown that these catalysts have substantial advantages over existing catalysts, including activity at room temperature, high turn overs and good to excellent asymmetric induction. The mechanism of the asymmetric induction will be investigated by NMR studies, kinetic and related studies, and by the synthesis of potential intermediates.The use of the catalysts in related reactions such as the addition if cyanide to imines, ring opening of expoxides and azirinides by cyanide, and use of other nucleophiles such as trimethylsilyl azide and silyl enol ethers will also be investigated.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bangor.ac.uk |