| EPSRC Reference: |
GR/M10007/01 |
| Title: |
A NEW C-GLYCOSIDATION PROCEDURE VIA ANOMERIC HETEROATO M TO CARBON REARRANGEMENTS OF TETRAHYDROPYRANYL ETHER |
| Principal Investigator: |
Ley, Professor S |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 1998 |
Ends: |
30 April 2001 |
Value (£): |
153,204
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The vast majority of tetrahydropyran and tetrahydrofuran containing natural products possess one and often two carbon-carbon bonds adjacent to the heteroatom. Likewise, many drugs and agrochemicals contain similar bonding arrangements. For this reason new methods for the construction of carbon-carbon bonds adjacent to the heteroatom in such systems is of considerable importance. We have devised a new strategy to these systems based on a simple concept of rearrangement of anomerically linked substrates to their corresponding carbon linked products upon treatment with Lewis acids. We believe this to be a very general reaction process and all initial experiences are encouraging. We now wish to expoilt these observations to determine the scope of the process by varying the ring size, the substrate linker and the heteroatom arrangements. These methods would then be applied to complex biologically active molecule assembly.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |