| EPSRC Reference: |
GR/M04402/01 |
| Title: |
SAFETY CATCH LINKER TECHNOLOGIES FOR COMBINATORIAL SOLID PHASE ORGANIC SYNTHESIS |
| Principal Investigator: |
Balasubramanian, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
31 March 2002 |
Value (£): |
48,646
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposal described the synthesis and exploration of two novel safety-catch linkers for use in solid phase organic synthesis. These linkers should open up new synthetic possibilities for combinatorial chemistry. The work will involve some basic research relating to the study of organic synthesis and mechanism and the linkers to be developed will be of strategic interest. The project will also involve training of a postdoctoral worker and a PhD student in this rapid growth area. The first study is based around an oxazolidine structure that will liberate amino alcohol derivatives upon cleavage. Such compounds are important building blocks for organic synthesis. A number of further studies are proposed around this linker to explore the mechanism and synthetic scope. The second linker is based around the cleavage mechanism for 1, 3- diol systems which has been termed retro conjugate addition for the purposes of the proposal. The work will shed some light on the mechanism of cleavage of 1,3-diols. This linker should also act as a single carbon donor, but has potential to be developed as a multi-carbon donor for solid phase organic synthesis.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |