Details of Grant 

EPSRC Reference:	GR/L88535/01
Title:	JREI: NMR SPECTROSCOPY AT 8.5T (360MHZ)
Principal Investigator:	Sadler, Dr I
Other Investigators:	Reed, Dr D Sadler, Professor P
Researcher Co-Investigators:
Project Partners:	Bruker GlaxoSmithKline plc (GSK)
Department:	Sch of Chemistry
Organisation:	University of Edinburgh
Scheme:	JREI
Starts:	01 March 1998	Ends:	28 February 2001	Value (£):	90,000
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
It is proposed to upgrade the ageing electronics of a 17 year old 360MHzNMR spectrometer to the state of the art technology to provide essential support for existing and new high quality industrially relevant research programs in synthetic, mechanistic and structuralorganic, inorganic and biological chemistry. The research programs that the spectrometer will support include the development of high yield stereoselective synthetic routes to oligosaccharides, glyco-conjugates, C-saccharides and peptides; the synthesis of heterocyclic molecules of importance in the drug and photographic industries; the electrochemical synthesis of conducting polymers; development of enantioselective catalysts for asymmetric syntheses; synthesis of heavy metal hydrides and homo- and heterometallic poynuclear complexes; investigation of the conformational behaviour of oligosaccharide derivatives in solution; the development and application of NMR techniques for the study of main-group cluster compounds, identification of molecular cross links and oligosaccharides in plant cell walls; determination of the structure and stereochemistry of terpene glycosides; mechanistic studies on electrocyclisation reactions; chemistry of metals in medicine, and the design, synthesis and behaviour of metallo drugs. This work can only progress satisfactorily if our 360mhz spectrometer has electronic modules which are stable and of the most recent technology to allow new, in addition to well-established, NMR techniques to be implemented.
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Organisation Website:	http://www.ed.ac.uk