| EPSRC Reference: |
GR/L86753/01 |
| Title: |
NON-INVASIVE MEASUREMENT OF CEREBRAL TEMPERATURE IN NEW BORN INFANTS BY MULTI-FREQUENCY MICROWAVE RADIOMETRY |
| Principal Investigator: |
Hand, Professor J |
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| Department: |
Medical Physics |
| Organisation: |
Royal Postgraduate Medical School |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
20 April 1998 |
Ends: |
19 September 2001 |
Value (£): |
167,973
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| EPSRC Research Topic Classifications: |
| Instrumentation Eng. & Dev. |
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Clinical implementation of hypothermic rescue therapy for reduction of neurodevelopment impairment of new born infants suffering from birth asphyxia is currently hindered by the difficulty in measuring brain temperature accurately and non-invasively.Multifrequency micorwave radiometry, together with a realistic description of the receiving antenna and the use of thermal modelling, can retrieve temperature at depths of 40mm with a precision of better than 0.5 degC. Using an MRI derived model of the newborn baby head, we shall optimise a 5 band radiometer (central operating frequencies, antenna design) for retrieving temperatures from the diencephalon and basal ganglia.We shall construct a separate Dicke radiometer operating in the radiation balance mode for each frequency band and compare measured brightness temperatures to those computed from a model of the temperature profile beneath the receiving antenna and, by interaction, adjust model parameters to obtain the best statistical agreement with the measured data. The precision of the predicted temperature profile will be determined using a Monte Carlo techniques. The radiometer and temperature retrieval algorithms will be compared with direct measurements in phantoms and in piglets.Following validation, brain temperature in normal preterm and term infants and in those suffering from hypoxic-ischaemic injury will be measured.
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Key Findings |
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Potential use in non-academic contexts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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