| EPSRC Reference: |
GR/L83646/01 |
| Title: |
ORGANIC LIGANDS FOR TRANSITION METAL COMPLEXES RELATED TO COFACTORS OF MOLYBDENUM/TUNGSTEN ENZYMES |
| Principal Investigator: |
Joule, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 1998 |
Ends: |
30 April 2001 |
Value (£): |
146,957
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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The total synthesis of the transition metal pteridine (TMPT) ligand of the molybdenum and tungsten enzymes would be completed, then metal complexes synthesised for spectroscopic and biological comparisons with the natural systems.The synthesis of structurally modified analogues of the TMPT, including quinoxalines and pteridines, would be followed by formation of transition metal complexes from these, and then their electrochemical, spectroscopic and biological evaluation aimed at gaining information about the following aspects of the mechanism of action of these enzymes:a What geometry at the metal is essential for catalytic oxygen transfer activity?b What is the role of TMPT(s) in the catalytic process?c What is the form of TMPT at the active site during catalytic turnover?d Does the structure of the organic ligand remain the same throughout the catalytic process?e Is there interplay between the oxidation state of the metal and that of the TMPT?
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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