| EPSRC Reference: |
GR/L69008/01 |
| Title: |
A HIGHLY EFFICIENT SYNTHESIS OF MANZAMINE ALKALOIDS |
| Principal Investigator: |
Coldham, Professor I |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
10 November 1997 |
Ends: |
09 November 1998 |
Value (£): |
41,519
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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This proposal aims to provide a unique, highly efficient and rapid synthesis of the manzamine alkaloids. The chemistry involves, as its key step, a powerful and stereocontroled intermolecular azomethine ylide cycloaddition. This process sets up two new rings and three new chiral centres in a single step, to provide the ABCE rings of manzamines A, E and F. Ring D will be constructed from this tetracycle and the total synthesis completed in what should be the shortest and most efficient route to date. The manzamines are an important class of marine alkaloids with significant biological activity as antileukemic and antibacterial agents.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |