| EPSRC Reference: |
GR/L61743/01 |
| Title: |
SELECTIVE CYCLIZATIONS FOR TETRAHYDROFURANS AND TETRAHYDROPRANS |
| Principal Investigator: |
Procter, Professor G |
| Other Investigators: |
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| Department: |
Synthetic Chemistry (Res Cen) |
| Organisation: |
University of Salford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
01 October 2000 |
Value (£): |
46,653
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We have recently discovered the unexpectedly selective formation of both tetrahydrofurans and tetrahydropyrans, using cyclisation precursors which are either 1, 2-diols or their derivatives. As such systems are easy to prepare using asymmetric dihydroxylation methods, if these observations prove to be general, then this could constitute an attractive general strategyto these systems. In particular, tetrahydrofuran and tetrahydropyran units can be found in many matural products with potentially useful biological activity. Following the results of methodology investigations, the total synthesis of appropriate target structures will be addressed, with particular emphasis on the synthesis of antifungal natural products and analogues thereof.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.salford.ac.uk |