| EPSRC Reference: |
GR/L60166/01 |
| Title: |
STEREOSELECTIVE ALDOL REACTIONS OF COMPLEX ALPHA AMINO ALDEHYDES |
| Principal Investigator: |
Hulme, Professor A |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Edinburgh |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
30 September 2001 |
Value (£): |
48,533
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Amino alcohol containing compounds have been shown to have a wide range of biological activities, acting as antiviral agents, antifungal agents and immunoactivators. This proposal outlines new methods for the synthesis of specificaminopolyol motifs, and the application of this methodology to the synthesis of bioactive compounds such as the iminosugar nectrisine, and the gamma aminoacid found in the antifungal agent zwittermicin A.The complex issues of acyclic stereocontrol have provided a significant challenge to organic chemists in recent years. Central to this approach, which is notable for both its directness and flexibility, is the use of the aldol reaction. This is coupled to the use of highly functionalised alpha amino aldehydes. It is hoped that high levels of stereocontrol may be exerted over each of the chiral centres in the aminopolyol motifs, leading to efficient syntheses of the bioactive targets.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ed.ac.uk |