| EPSRC Reference: |
GR/L52550/01 |
| Title: |
PROCESS INDUCED CHANGES IN THE THERMODYNAMIC STATE OF ACTIVE INGREDIENTS IN SEMI SOLID MATRICES |
| Principal Investigator: |
Hadgraft, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Welsh School of Pharmacy |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
21 January 1998 |
Ends: |
01 September 2000 |
Value (£): |
120,599
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| EPSRC Research Topic Classifications: |
| Complex fluids & soft solids |
Materials Processing |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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We have demonstrated the utility of producing supersaturated systems for the optimised delivery of topical drugs. However, a rational description of process parameters in this area has not been investigated. We wish to determine how process parameters such as formulation content, mixing and temperature affect the ability to form and control supersaturated states in semi solids. In certain circumstances we need to prevent the crystallisation process since this will result in reduced product performance with time. This may be achieved by appropriate additives such as anti nucleant polymers. No structure activity relationships are available for these. We have also demonstrated that this type of additive can be used in controlled crystallisation. We wish to examine their role in the controlled production of colloidal dispersions within semi solid matrices. This will also be affected by physical parameters such as temperature and mixing.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |