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Details of Grant 

EPSRC Reference: GR/L23642/01
Title: SOLVENT & PRESSURE CONTROL OF ORGANIC CRYSTALLIZATION APPLICATION TO PHARMACEUTICALS
Principal Investigator: Shekunov, Dr B
Other Investigators:
Aulton, Professor M Norton-Wayne, Dr L Armitage, Dr D
Researcher Co-Investigators:
Project Partners:
AstraZeneca
Department: Unknown (Data Transfer)
Organisation: De Montfort University
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 1996 Ends: 31 December 1996 Value (£): 68,033
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Design of Process systems
Materials Synthesis & Growth
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
The main aim of this project is to develop new clean methodology for crystallization of expansive organic materials, particularly, inhalation pharmaceuticals. This purpose will be achieved by using two prinicple techniques: recrystallization from supercritical fluids (SCF) and high-pressure crystallization. Novel in situ analytical methods, based on ultra-fast interferometry, will be developedto study the phase diagrams, particle formation and fluid hydodynamics. This programme will enable us to create a fundamental apporach to such phenomena and to apply this methodology to a variety of drugs. This work will be performed in a close industrial collaboration with Astra Charnwood (Loughborough).
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Further Information:  
Organisation Website: http://www.dmu.ac.uk