| EPSRC Reference: |
GR/L23239/02 |
| Title: |
STUDIES ON THE ORIGIN OF RNA AND AMINOACYL-RNA |
| Principal Investigator: |
Sutherland, Professor J |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1998 |
Ends: |
31 October 1999 |
Value (£): |
64,998
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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It is proposed to investigate a potential aldol reaction-based prebiogenesis of RNA and aminoacyl-RNA. The work entails the preparation of a number of achiral biscarbonyl monomers and investigating their solution-phase structure and reactivity at various pH values. A series of dehydrooxazine-2-ones is an additional synthetic target; these compounds have the constitutional potential to be performed by the ring-opening of oxirane carbonitrile and derivatives by amino acids and to participate in the proposed aldolisation giving RNA terminated at its 3'-terminus by an aminocyl group.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
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| Summary |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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