| EPSRC Reference: |
GR/L22683/01 |
| Title: |
STUDIES ON OPTIMISATION AND SCOPE OF A NOVEL CATALYTIC CYCLE FOR USE IN SYNTHESIS |
| Principal Investigator: |
Murphy, Professor JA |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1996 |
Ends: |
31 January 2000 |
Value (£): |
210,464
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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The factors which limit the catalytic turnover number of tetrathiafulvalene (TTF) to 20 in radical-polar crossover chemistry will be investigated. A number of clues suggest at least three candidate reactions. The prducts of catalysts destruction will be isolated and identified, and this information will be used in the design of improved catalysts.New nitrogen-containing catalysts will be prepared which are more sterically encumbered, with the aim of increasing the catalytic turnover number. The catalytic power of these catalysts and the comparative kinetics of combination of their radical cations with carbon radicals will be tested on diaxonium salt substrates in (i) simple cyclisation reaction, (ii) tandem cyclisation reactions and (iii) intermolecular reactions. Such nitrogen-containing catalysts are better electron donors than TTF, and this fact will be exploited in extending the range of substrates which undergo radical-polar crossover chemistry. Their oxidation potential will be tested by cyclic voltammetry to gain an appropriate idea of their reducing power. They will then be reacted with appropriate alkyl halides.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |