| EPSRC Reference: |
GR/L01756/01 |
| Title: |
NOVEL REAGENTS AND PATHWAYS FOR SELECTIVE FLOURINATION OF ORGANIC MOLECULES |
| Principal Investigator: |
Motherwell, Professor WB |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1996 |
Ends: |
30 September 1999 |
Value (£): |
6,396
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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We have shown that hypervalent iodoarene difluorides are readily prepared and display a great affinity for nucleophilic sulfur. These reagents and inexpensive equivalents such as N-iodosuccinimide and pyridine HF will be used to transform xanthates and thiono-phosphinates into fluorides, thioncarbonates into vicinal fluorohydrins and dithiorthoesters into gem difluoroalkyl ethers. The ability of iodoarene difluorides to function as reagents for pretense electrophilic fluorination will also be tested with silyl ester enolates and nitronates.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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