| EPSRC Reference: |
GR/K95901/01 |
| Title: |
TOTAL SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLIC NATURAL PRODUCTS |
| Principal Investigator: |
Thomas, Professor EJ |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1996 |
Ends: |
31 January 1999 |
Value (£): |
94,288
|
| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
|
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
It is proposed to complete a total synthesis of the macrocyclic antibiotic lankacidin C. key steps will be the stereoselective acylation of an azetidinone, an intermolecular transacylation of the azetidinone to give the six-membered lactone fragment, and the macrocylisation step. Once this synthesis is complete, we will continue on a different synthesis, namely a synthesis of the insecticidal alkaloid stemofoline.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|