| EPSRC Reference: |
GR/K92764/01 |
| Title: |
ROPA REMOTE ASYMETRIC INDUCTION USING CHIRAL IRON COMPLEXES |
| Principal Investigator: |
Ley, Professor S |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
ROPA |
| Starts: |
01 November 1996 |
Ends: |
31 October 1998 |
Value (£): |
93,478
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Summary on Grant Application Form |
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We propose to use the inherent chirality of tricarbonyliron lactone complexes to devise new ways to generate remote stereocentres. The rigidity of the tether, in addition to the steric bulk of the tricarbonyliron moiety has the effect of directing the addition of nucleophiles to one face of a carbonyl group positioned in the vicinity of the allyl system. We propose to investigate asymmetric alkylation of silyl enol ethers. Mukaiyama aldol reactions, 1, 4-additions to enones, generation of quaternary centres and stereoselective ring synthesis.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |