| EPSRC Reference: |
GR/K90289/01 |
| Title: |
NEW SYNTHETIC METHODS INVOLVING CLAISEN REARRANGEMENTS (ROPA) |
| Principal Investigator: |
Holmes, Professor AB |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
ROPA |
| Starts: |
01 July 1997 |
Ends: |
30 June 1999 |
Value (£): |
71,142
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| EPSRC Research Topic Classifications: |
| Materials Synthesis & Growth |
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Summary on Grant Application Form |
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The ring expansion[3.3] sigmatropic rearrangement of vinyl substituted ketene acetals and animals derived from 1, n-diols and aminoacohols will be used in a tandem metathesis/Claisen strategy directed toward medium ring lactones and lactams. Medium ring stereocontrol will be employed to functionalise these products stereo- and regioselectively. The cis-double bond produced in the claisen rearrangement will be functionalised stereoselectivity under allylic stereocontrol to give novel building blocks for the synthesis of polyketide and alkaloid natural products. A two directional ring fusion strategy will be developed to assemble fused polyether structures. This will be applied to the core nine-membered ring-containing fragment of the polyether toxin ciguatoxin.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |