| EPSRC Reference: |
GR/K82956/01 |
| Title: |
REACTIVITY AND MECHANISMS OF REACTIONS OF FOUR MEMBERED AZAPHOSPHETIDINE RINGS |
| Principal Investigator: |
Page, Professor M |
| Other Investigators: |
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| Department: |
Chemical and Biological Sciences |
| Organisation: |
University of Huddersfield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1996 |
Ends: |
30 September 1999 |
Value (£): |
51,242
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| EPSRC Research Topic Classifications: |
| Physical Organic Chemistry |
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Summary on Grant Application Form |
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Four membered rings are unusual in that they do not always display their thermodynamic instability in the reactivity of their ring opening reactions. Azaphosphetidines undergo a rapid base catalysed hydrolysis in water. We propose to identify the factors controlling reactivity and to investigate the mechanism of their reactions using linear free energy relationships, isotope and solvent effects. These derivatives are potentially useful as b-lactamase inhibitors and for catalytic antibody design for synthesising four membered rings.+
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hud.ac.uk |