| EPSRC Reference: |
GR/K74821/01 |
| Title: |
SUPPORTED HOMOGENOUS CATALYSTS FOR MULTIPLE SIMULTANEOUS ASSAY |
| Principal Investigator: |
Brown, Dr JM |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 1995 |
Ends: |
31 May 1999 |
Value (£): |
148,159
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Combinatorial Chemistry |
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Summary on Grant Application Form |
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The optimum procedures for catalytic organic synthesis are conventionally discovered by trial and error, which is time-consuming. For the particular case of asymmetric catalysis this implies either experiments with a number of ligand-metal complexes, or with variation of solvent and reaction conditions, or both. The proposal suggests ways in which this process can be facilitated, with the further potential advantage that homogeneous catalysts are replaced by polymer-supported analogues. In two distinct series, it is proposed that a number of structurally related catalysts can be prepared using the methods of combinatorial chemistry, in a multistep synthesis. In this way a moderate number [10-10] of ligands supported on polymer beads bearing identifying tags can be synthesised, and reacted with an appropriate metal complex to produce the catalyst precursor. Methods for the simultaneous assay of several catalytic transformations will be developed, as discussed herein.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |