| EPSRC Reference: |
GR/K69179/01 |
| Title: |
A COMBINATORIAL TEMPLATING AND SELECTION APPROACH TO CATALYTIC RECEPTORS |
| Principal Investigator: |
Sanders, Professor J |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 1996 |
Ends: |
30 September 1999 |
Value (£): |
237,453
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Summary on Grant Application Form |
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We proposd a new chemical combinatorial/selection approach to creating receptors which are capable of recongition, catalysis and sensing. The approach has the potential to combine the most powerful aspects of selection with the control characteristic of designed, synthetic systems. In effect we are proposing to explore the synthetic chemist's equivalent of catalytic antibodies, using a cocktail of components that are combined to create the optimum host system for any chose transition state (TS): a TS-analogue selects from the cocktail those components that bind it best. Under thermodynamic, equilibrating conditions, incorrect bond-making will be proof-read and, on average, rejected. The final solution may contain millions of species, but the TS- analogue will be tethered to a bead and will readily be isolated by the mixture together with its ideal, catalytically-active host. Preliminary unpublished results demonstrating novel thermodynamic templating effects are presented to demonstrate that the approach and the chemistry are viable.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |