Details of Grant 

EPSRC Reference:	GR/K68226/01
Title:	A TOTAL SYNTHESIS OF MANZAMINE A
Principal Investigator:	Clark, Professor J
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Chemistry
Organisation:	University of Nottingham
Scheme:	Standard Research (Pre-FEC)
Starts:	03 January 1996	Ends:	02 March 1999	Value (£):	142,330
EPSRC Research Topic Classifications:	Biological & Medicinal Chem.
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Summary on Grant Application Form
Manzamine A is a member of a family of alkaloids of marine origin, which have been shown to possess significant anti-tumour and anti-bacterial activity. The formidable synthetic challenges presented by the structural complexity of the manzamines, coupled with their significant biological activity, has stimulated many synthetic endeavours towards the preparation of sub-units of these alkaloids.The aim of the work outlined in our proposal is the efficient synthesis of manzamine A by a strategy which is conceptually novel and employs new metal-catalysed reactions for ring construction. The pivotal transformations in our route will be the tandem catalytic generation and rearrangement of an ammonium ylide to establish the ACE ring system, and a carbenoid C-H-insertion reaction to construct the D ring and complete the tetracyclic core framework.
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Organisation Website:	http://www.nottingham.ac.uk