| EPSRC Reference: |
GR/J83192/01 |
| Title: |
ACTIVE SITE STUDIES ON DEHYDROQUINASES |
| Principal Investigator: |
Coggins, Professor J R |
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| Project Partners: |
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| Department: |
School of Life Sciences |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 1994 |
Ends: |
31 March 1997 |
Value (£): |
131,409
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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Summary on Grant Application Form |
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To extend mechanistic studies and support crystallographic work on the two classes of dehydroquinase by:1. Identifying the carboxylate binding sites of the two types of enzyme.2. Identifying other active site residues in the type II enzyme.3. Developing in collaboration with Dr C Abell (Cambridge) class specific inhibitors for the enzymes.4. Using chemical modification and site-directed mutagenesis to study the mechanisms and active site chemistry of the two classes of enzyme.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |